POINT 3: Response by Paul Melters to Steve Slott from a previous date - August 29, 2013

Steve Slott

You wrote:

SLOTT: #3 "The fractional retention or balance of fluoride at any age depends on the quantitative features of absorption and excretion. For healthy, young, or middle-aged adults, approximately 50 percent of absorbed fluoride is retained by uptake in calcified tissues, and 50 percent is excreted in the urine. For young children, as much as 80 percent can be retained owing to increased uptake by the developing skeleton and teeth (Ekstrand et al., 1994a, b). Such data are not available for persons in the later years of life, but based on bone mineral dynamics, it is likely that the fraction excreted is greater than the fraction retained.

Under most dietary conditions, fluoride balance is positive. Whether it is positive or negative appears to be due to the bloodbone fluoride steady state. When chronic intake is insufficient to maintain or gradually increase plasma concentrations, fluoride excretion by infants (Ekstrand et al., 1984) and adults (Largent, 1952) can exceed the amounts ingested due to mobilization from calcified tissues."

PM RESPONSE: Thank you for citing these lines form the IOM report. It is obvious that you have no real idea of what it is that you are talking about, and are grasping at straws. The info above actually supports what I am saying, but you are so ignorant, you can't even see that. If you want to discuss positive and negative fluoride balances and fluoride accumulation in the elderly - sure, we can do that. Some other day. Unfortunately, this is not what was asked from you.

You were asked to provide SPECIFIC reference to the following statement:

3) Slott: "The 2.5-5.0 mg per day will not allow sufficient plasma concentrations to maintain the bone levels of fluoride at that which will risk skeletal fluorosis."

Please provide the scientific reference for this, with the intake figures as those you mention.