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Johnson False Statement/Bogus Citations #9

“Severe dental fluorosis is not an adverse health effect”

The following question was posed to Johnny Johnson on numerous occasions, on a variety of blogs. An answer was never received until September 4, 2013. His answer and the resulting exchange is listed below.

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ORIGINAL QUESTION:

To Johnny Johnson

I've asked you this before, but you always avoid answering.

As you seem to be such an expert on dental fluorosis, perhaps you could tell me about the exact mechanism which leads to severe dental fluorosis? Surely, you must know about these mechanisms is you declare such a condition to be of "cosmetic concern only"?  

REFERENCE:__________________

For some reason I can only find a bunch of papers which state "exact mechanism not yet known", or "still unknown".  

After all, you state that severe dental fluorosis is not an adverse health effect, an opinion that - of course - was not shared by the majority of the NRC committee members.

As a matter of fact, the NRC summary you cite states that only 2 of the 12 members thought such nonsense.  
http://www.nap.edu/openbook.php?record_id=11571&page=4

You see, there is a lot of new evidence emerging that it is actually caused by thyroid hormone dysfunction. But surely, you would know more, so please do tell me and the other readers. Are there any studies done in the US on dental fluorosis and thyroid dysfunction?

REFERENCE:___________________  

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On September 4, Johnson responded as follows:

Here's 2 good references for you: 

The nature and mechanisms of dental fluorosis in man.
http://www.ncbi.nlm.nih.gov/pubmed/2179331 

Biological mechanisms of dental fluorosis relevant to the use of fluoride supplements. 
http://www.ncbi.nlm.nih.gov/pubmed/10086925

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Melters responded:

You seem to be having some troubles understanding what is being asked from you. 

NOWHERE in the two papers you cite is the exact mechanism described that leads to dental fluorosis. 

Do YOU see it in anywhere in the 1990 paper by Feyerskov? Or the other one you cite by DenBesten from 1999?

No, because it's not there. Even DenBesten states "The specific mechanisms by which fluoride causes the changes leading to enamel fluorosis are not well defined".

Below is another paper by her from 2008. She still doesn't know. 

Even your friend Prof. Bawden writes: 

"Despite extensive investigation, the developmental mechanism or mechanisms resulting in dental fluorosis are unknown". 

Wright JT, Chen SC, Hal KI, Yamauchi M, Bawden JW - "Protein Characterization of Fluorosed Human Enamel." Dent Res 75(12):1936 (1996) 

He seems a lot more honest than you. 

In case you need some more, recent, evidence to prove that still NOBODY knows, have a look at the cites below. 

However, you being the expert and all that, are always welcome to supply just ONE reference. 

Reference:_______________________ 

"Currently the molecular mechanism responsible for dental fluorosis remains unknown..." 
Sierant ML, Bartlett JD -"Stress Response Pathways in Ameloblasts: Implications for Amelogenesis and Dental Fluorosis" Cells 1(3):631-645 (2012) 

"..the underlying mechanism is unclear." 
Wei W, Gao Y, Wang C, Zhao L, Sun D "Excessive fluoride induces endoplasmic reticulum stress and interferes enamel proteinases secretion" Environ Toxicol. 28(6):332-41(2013) 

"The mechanisms by which fluoride affects enamel formation to result in fluorosis are not fully understood." 
Tanimoto K, Le T, Zhu L, Chen J, Featherstone JD, Li W, DenBesten P - "Effects of fluoride on the interactions between amelogenin and apatite crystals" J Dent Res 87(1):39-44 (2008) 

"...the precise mechanisms are unclear." 
Moseley R, Waddington RJ, Sloan AJ, Smith AJ, Hall RC, Embery G - "The influence of fluoride exposure on dentin mineralization using an in vitro organ culture model" Calcified Tissue International 73:470-5 (2003) 

"The molecular mechanisms that underlie the pathogenesis of dental fluorosis are not known."  
Everett ET, McHenry MA, Reynolds N, Eggertsson H, Sullivan J, Kantmann C, Martinez-Mier EA, Warrick JM, Stookey GK - "Dental fluorosis: variability among different inbred mouse strains" J Dent Res. 81(11):794-8 (2002).

"....the exact mechanism leading to dental fluorosis is not fully understood." 
Susheela AK, Bhatnagar M. - "Structural aberrations in fluorosed human teeth: Biochemical and scanning electron microscopic studies" Current Science 77:1677-80 (1999) 

"...the mechanism of F(-)-induced toxicity is unclear." 
Sharma R, Tsuchiya M, Bartlett JD - "Fluoride induces endoplasmic reticulum stress and inhibits protein synthesis and secretion" Environ Health Perspect 116(9):1142-6 (2008) 

"Despite extensive investigation, the developmental mechanism or mechanisms resulting in dental fluorosis are unknown."
Chaturvedi R, Kaur M, Gauba K, Bhalla S - "Dental Fluorosis: An update" Indian J Dent Ed 4(1/2):23 (2011)

Oh - and I seem to have missed your response to my other question: 

You see, there is a lot of new evidence emerging that it is actually caused by thyroid hormone dysfunction. But surely, you would know more, so please do tell me and the other readers. Are there any studies done in the US on dental fluorosis and thyroid dysfunction? 

REFERENCE:___________________

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Johnny Johnson responded:

Perhaps you might want to take your creationism arguments up with the Good Lord upstairs. 

Want absolute proof that you exist? Prove you don't. 

Dr. DenBesten is one of the premier fluoride researchers in the United States. Since Dr. Jim Bawden isn't here to field your empty claims, and God's not ready for you, perhaps you'll want to take it up with someone more cerebral than I with amelogenesis and fluoride incorporation. Certainly, it's way over your head. 

Have fun with that one. 

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Melters responded:

I am not surprised at your empty words here. Of course you don't have a response - as usual. 

I will make sure to save your answers here and get them posted on fluoridedentalexperts.com

That way, we don't aways have to rehash the same issues. People elsewhere will be able to clearly see your "expertise", and how empty your claims really are. 

And you pretend to be acting on behalf of children? Shame on you. 

Paul
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(July 8, Stanford Patch)