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Point #3: Response by Paul Melters to Steve Slott, DDS - September 5, 2013

To Steve Slott

You wrote:

SLOTT:#3 "The fractional retention or balance of fluoride at any age depends on the quantitative features of absorption and excretion. For healthy, young, or middle-aged adults, approximately 50 percent of absorbed fluoride is retained by uptake in calcified tissues, and 50 percent is excreted in the urine. For young children, as much as 80 percent can be retained owing to increased uptake by the developing skeleton and teeth (Ekstrand et al., 1994a, b). Such data are not available for persons in the later years of life, but based on bone mineral dynamics, it is likely that the fraction excreted is greater than the fraction retained.

Under most dietary conditions, fluoride balance is positive. Whether it is positive or negative appears to be due to the bloodbone fluoride steady state. When chronic intake is insufficient to maintain or gradually increase plasma concentrations, fluoride excretion by infants (Ekstrand et al., 1984) and adults (Largent, 1952) can exceed the amounts ingested due to mobilization from calcified tissues."

http://www.ncbi.nlm.nih.gov/books/NBK109832/

PM Response: Again - I already responded to this previously. (3)

You seem to be having a tough time understanding this. 

To remind you:

You had claimed the following:

Slott: "The 2.5-5.0 mg per day will not allow sufficient plasma concentrations to maintain the bone levels of fluoride at that which will risk skeletal fluorosis."

This is truly one of the most absurd statements I have yet to see - anywhere. You were asked to provide a scientific reference for this statement, involving such intake figures as you cite above.

You are now - again - not providing a reference to this at all. You are citing some lines from the 1997 IOM report without really understanding a) what has been asked from you, and b), what it is you are actually citing.

A reference from the 1977 NAS/NRC report has been provided to you many times over, which clearly stated:
 


"...a retention of 2 mg/day would mean that an average individual would experience skeletal fluorosis after 40 years..." 

Drinking Water and Health, Safe Drinking Water Committee, National Academy of Sciences, NAS/NRC, 1977 p. 372 - Available via the NAP website.http://www.nap.edu/ 
http://www.nap.edu/openbook.php?record_id=1780&page=372

According to your own citation above, this retention of 2 mg/day is achieved by ingesting 4 mg/day (50% = 2 mg). (Children retain more.)

If you still have do not understand this most basic tenet of fluoride toxicology I suggest you read Response #2 a few more times. I can’t make it any simpler than that.

If you want to discuss positive and negative fluoride balances, we can do that. But that’s not what this is about.

Once again - please provide a reference for your statement:

Slott: "The 2.5-5.0 mg per day will not allow sufficient plasma concentrations to maintain the bone levels of fluoride at that which will risk skeletal fluorosis."

As you and your “dental expert” friends like to say so often: “You are entitled to your own opinion - you are not entitled to your own facts.”

Paul