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Point #2: Response by Paul Melters to Steve Slott, DDS - September 4, 2013
Background: On countless blogs and comment sections Slott claims that “there are no adverse health effects below 10 mg a day.” Or he states: "A daily intake of fluoride from all sources of less than 10 mg per day will result in NO adverse effects LONG or SHORT term."
This, of course, is complete nonsense.
Fluoride toxicity depends on both dose AND duration. 10 mg/day for how long? In the case of dental fluorosis, it depends on dose AND duration AND time of exposure.
This is a basic principle of fluoride toxicology, and the very reason why there is a MCL set for fluoride in drinking water, as well as pesticide regulations, or occupational exposure limits.
It is a well established scientific fact that fluoride in bone increases with age and linearly in relation to fluoride intake.
"Crippling skeletal fluorosis might occur in people who have ingested 10-20 mg of fluoride per day for 10-20 years."
(National Research Council. 1993. Health Effects of Ingested Fluoride. National Academy Press, Washington DC. pg. 59) SEE OTHER REPORTS
Melters informed Slott that 10-20 mgs for 10 to 20 years is the same as 2.5 to 5 mgs for 40 to 80 years.
Slott: ...Absurdities such as your own ridiculous attempt to extrapolate "10-20 mg/day for at least 10 years" into being the "same" as "2.5 -5 mg for 40-80 years" is an excellent example of how antifluoridationists claim "science" to support their position.
Slott was asked to show how this established scientific fact was in any way "absurdist" or
Supporting material from a 1977 National Research Council/National Academy of Science report was supplied - once again:
"...a retention of 2 mg per day would mean that an average individual would experience skeletal fluorosis after 40 years..."
[Drinking Water and Health, Safe Drinking Water Committee, National Academy of Sciences, NAS/NRC, 1977 p. 372 - Available for FREE via the NAP website.
SLOTT: "#2 The human body is far too complex to assume that the process of fluoride retention and excretion can be neatly split into equal mathematical portions over a lifetime. To not understand this is to not understand the mechanisms of substance interactions within the human body, whatsoever.
Here is my response to your post concerning Point #2.
SLOTT: "#2 The human body is far too complex to assume that the process of fluoride retention and excretion can be neatly split into equal mathematical portions over a lifetime. To not understand this is to not understand the mechanisms of substance interactions within the human body, whatsoever. Positive and negative plasma fluoride balances are the determining factors."
On August 29, 2013 you provided two different responses to this Point #2. [See: (1) and (2)]. My response to your first comment (1) is posted elsewhere (1b).
The comment above is the same as (2), posted previously on August 29, 2013, and was already addressed in detail (see Point 2 b, August 29, 2013). You were asked to provide a scientific reference for this - almost comical - statement, and were unable to do so.
For the benefit of the reader:
For over 80 years it has been established that fluoride is a "cumulative toxin" - it accumulates in the body.
A healthy adult may excrete 50% of what is taken in - the rest gets stored in the body, mainly in bone and teeth. Children retain more (up to 80%), as their bones are still growing.
Fluoride effects on bone depend on dose AND duration.
"The total quantity of fluoride ingested is the single most important factor in determining the clinical course of skeletal fluorosis (Krishnamachari, 1986); the severity of symptoms correlates directly with the level and duration of exposure (Fisher et al, 1989)."
[Review of Fluoride Benefits and Risks, Department of Health and Human Services, February 1991 , page 45]
To make it very simple:
If my fluoride intake is 10 mg/day, I will retain 5 mg (50%) and that gets stored in my bones/teeth.
If my fluoride intake is 5 mg/day, then I will retain 2.5 mg (50%) which gets stored in bones/teeth.
After ingesting fluoride at 10 mg/day for 10 years, the amounts of fluoride stored in bone will be comparable to those observed when ingesting 5 mg/day for 20 years, or 2.5 mg/day for 40 years.
Steve Slott has a very tough time understanding this concept, although it is the basis of any and all exposure regulations all over the world, be it to protect workers exposed to fluorides in the
workplace, or water contaminant levels (MCL).